Article 11418

Title of the article

STUDY OF THE GENETIC FEATURES OF ANTIOXIDANT ENZYME CODING
IN CHRONIC GENERALIZED PARODONTITIS 

Authors

Trofimov Vladimir Aleksandrovich, Doctor of biological sciences, professor, head of the sub-department of genetics, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: geneticlab@yandex.ru
Vlasova Tat'yana Ivanovna, Doctor of medical sciences, professor, sub-department of normal and pathologic physiology, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: v.t.i@bk.ru
Kondyurova Evgeniya Viktorovna, Candidate of medical sciences, associate professor, head of the sub-department of denistry, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: vap.61@yandex.ru
Akimov Vladimir Vladimirovich, Applicant, sub-department of denistry, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: vap.61@yandex.ru
Tashina Elena Andreevna, Postgraduate student, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: vap.61@yandex.ru 

Index UDK

616.314.17-008.1:615.27 

DOI

10.21685/2072-3032-2018-4-11 

Abstract

Background. It is of interest to study the genetic features of the encoding of antioxidant enzymes in chronic generalized parotontitis. The purpose: to study the prevalence of polymorphisms of antioxidant enzyme genes in chronic generalized periodontitis and to reveal the relationship of the pathogenesis of this disease with the polymorphism of the genes of antioxidant enzymes.
Materials and methods: the study was conducted in 72 patients with chronic generalized periodontitis of moderate severity with a duration of disease of 5 to 12 years aged 30 to 50 years, treated at the Republican Dental Polyclinic of Saransk.
The frequency of occurrence of polymorphisms of genes of antioxidant enzymes of superoxide dismutase, catalase and glutathione of S-transferase P1 in patients with chronic generalized periodontitis was studied.
Results. In the genomes of patients, an increased incidence of pathological alleles of the superoxide dismutase genes, glutathione S-transferase was revealed. The work shows the association of Ala16Val mutations of the superoxide dismutase gene and Ala114Val glutathione S-transferase gene with the risk of developing chronic generalized periodontitis.
Conclusion. The obtained data testify to the important role played by the free radical mechanism in the realization of the pathogenesis of chronic generalized periodontitis, which determines the high risk of damage to cell membranes, the development of destructive processes and cell death, which is the basis for studying the genetic component associated with the presence of polymorphisms in the enzyme genes, affecting the effectiveness of antioxidant protection in the body of patients with this pathology. 

Key words

chronic generalized periodontitis, antioxidant system, genotype, polymorphism 

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References

1. Tsepov L. M. Zabolevaniya parodonta: vzglyad na problemu [Periodontal disease: view of the problem]. Moscow: MEDpress-inform, 2006, 192 p.
2. Gazhva S. I., Guluev R. S. Obozrenie. Stomatologiya [Viewing. Denistry]. 2012, no. 1, pp. 13–14.
3. Gupta A., Govila V., Saini Pro-teomics A. J. Oral Biol. Craniofac. Res. 2015, vol. 5, iss 1, pp. 46–52.
4. Seo J. Y., Park Y. J., Yi Y. A. Restor. Dent. Endod. 2015, vol. 40 (1), pp. 14–22.
5. Grudyanov A. I., Bezrukova I. V. Agressivnye formy parodontita [Agressive forms of periodontitis]. Moscow, 2002, 126 p.
6. Lukinykh L. M., Kruglova N. V. Obozrenie. Stomatologiya [Viewing. Denistry]. 2012, no. 1, pp. 14–16.
7. Kazarina L. N., Vdovina L. V. Obozrenie. Stomatologiya [Viewing. Denistry]. 2012, no. 1, pp. 20–21.
8. Gazhva S. I., Voronina A. I. Obozrenie. Stomatologiya [Viewing. Denistry]. 2010, no. 2, p. 14.
9. Zorina O. A., Boriskina O. A. The Scientific & Educational Bulletin "Health & Educational Millennium". 2012, vol. 14, no. 5, pp. 1–3.
10. Atrushkevich V. G., Zyablitskaya M. S. Polimorfizm gena VDR i parodontit [Polymorphism of the VDR gene and periodontitis]. 2011, Available at: http://www.stomport.ru/articlepro_show_id_337.
11. Cantore S., Mirgaldi R., Ballini A., Coscia M. F., Scacco S., Papa F. et al. International Journal of Medical Sciences. 2014, vol. 11, pp. 674–679.
12. Egorov D. Yu., Kozlov A. V. Priroda produktov POL, opredelyaemaya v syvorotke krovi po reaktsii s 2-tiobarbiturovoy kislotoy [The nature of lipid peroxidation products determined in serum by reaction with 2-thiobarbituric acid]. Dep. v VINITI 30.08.88, № 6766. V-88. Moscow, 1988, 11 p.
13. Gurevich V. S., Kontorshchikova K. N., Shatalina L. V. Laboratornoe delo [Laboratory work]. 1990, no. 4, pp. 44–47.
14. Maksimovskiy Yu. M. Stomatologiya dlya vsekh [Denistry for everybody]. 2006, no. 2, pp. 24–29.
15. Tsarev V. N., Nikolaeva E. N. Stomatologiya [Denistry]. 2010, no. 6, pp. 19–23.
16. Men'shchikova E. B., Zenkov N. K., Lankin V. Z. Okislitel'nyy stress: patologicheskie sostoyaniya i zabolevaniya [Oxidative stress: pathological conditions and diseases]. Novosibirsk: ARTA, 2008, 284 p.
17. Kapel'ko V. I. Russkiy meditsinskiy zhurnal [Russian medical journal]. 2003, vol. 11, no. 21, pp. 1185–1188.

 

Дата создания: 17.06.2019 13:36
Дата обновления: 17.06.2019 15:15